INTELLIGENCE ENGINEERING'S ALPHABET : World Class Biobrains: Drew Endy, Matt Scullin, Daniel Swiger++- BI BioIntelligence, the most collaborative human challenge Mother Earth has ever staged?
NB any errors below are mine alone chris.macrae@yahoo.co.uk but mathematically we are in a time when order of magnitude ignorance can sink any nation however big. Pretrain to question everything as earth's data is reality's judge
Its time to stop blaming 2/3 of humans who are Asian for their consciously open minds and love of education. Do Atlantic people's old populations still trust and celebrate capability of generating healthy innovative brains? What's clear to anyove visting Washington DC or Brussels is a dismal mismatch exists between the gamechanging future opportunities listed below and how freedom of next generation learning has got muddled by how old male-dominated generations waste money on adevrtising and bossing. Consider the clarity of Stanford's Drew Endy's Strange Competition 1 2:
Up to “60% of the physical inputs to the global economy”7 could be made via biotechnology by mid-century, generating ~$30 trillion annually in mostly-new economic activity. 8 Emerging product categories include consumer biologics (e.g., bioluminescent petunias,9 purple tomatoes,10 and hangover probiotics11 ), military hard power (e.g., brewing energetics12 ), mycological manufacturing (e.g., mushroom ‘leather’ 13 ), and biotechnology for technology (e.g., DNA for archival data storage14 ). Accessing future product categories will depend on unlocking biology as a general purpose technology15 (e.g., growing computers16 ), deploying pervasive and embedded biotechnologies within, on, and around us (e.g. smart blood,17 skin vaccines,18 and surveillance mucus19 ), and life-beyond lineage (e.g., biosecurity at birth,20 species de-extinction21 ).
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notes on drew endy testimony on bio tech 2025 strange competition

Natural living systems operate and manufacture materials with atomic precision on a planetary scale, powered by ~130 terawatts of energy self-harvested via photosynthesis

Biotechnology enables people to change biology. Domestication and breeding of plants and animals for food, service, and companionship began millennia ago. Gene editing, from recombinant DNA to CRISPR, is used to make medicines and foods, and is itself half-a-century old. Synthetic biology is working to routinize composition of bioengineered systems of ever-greater complexity

 https://colossal.com/  20 https://dspace.mit.edu/handle/1721.1/34914  19 https://2020.igem.org/Team:Stanford  18 https://med.stanford.edu/news/all-news/2024/12/skin-bacteria-vaccine.html  17 https://www.darpa.mil/news/2024/rbc-factory  16 https://www.src.org/program/grc/semisynbio/semisynbio-consortium-roadmap/  15 https://www.scsp.ai/2023/04/scsps-platform-panel-releases-national-action-plan-for-u-s-leadership-in-biotechnology/  14 https://dnastoragealliance.org/  13 https://www.mycoworks.com/  12 https://serdp-estcp.mil/focusareas/3b64545d-6761-4084-a198-ad2103880194  11  https://zbiotics.com/  10 https://www.norfolkhealthyproduce.com/  9 https://light.bio/     8 https://web.archive.org/web/20250116082806/https:/www.whitehouse.gov/wp-content/uploads/2024/11/BUILDIN G-A-VIBRANT-DOMESTIC-BIOMANUFACTURING-ECOSYSTEM.pdf  7 https://www.mckinsey.com/industries/life-sciences/our-insights/the-bio-revolution-innovations-transforming-econo mies-societies-and-our-lives     6 https://www.nationalacademies.org/our-work/safeguarding-the-bioeconomy-finding-strategies-for-understanding-ev aluating-and-protecting-the-bioeconomy-while-sustaining-innovation-and-growth   5 https://doi.org/10.1038/s41586-020-2650-9  

  4 https://www.nature.com/articles/s41467-023-40199-9

AIH- May 2025.Billion Asian womens end poverty networking 2006-1976 is most exciting case of Entrepreneurial Revolution (survey Xmas 1976 Economist by dad Norman Macrae & Romano Prodi). In 2007, dad sampled 2000 copies of Dr Yunus Social Business Book: and I started 15 trips to Bangladesh to 2018- many with apprentice journalists. This is a log of what we found - deepened after dad's death in 2010 by 2 kind remembrance parties hoist by Japan Embassy in Dhaka with those in middle of digital support of what happened next. We witnessed a lot of conflicts - i can try and answer question chris.macrae@yahoo.co.uk or see AI20s updates at http://povertymuseums.blogspot.com. I live in DC region but see myself as a Diaspoira Scot. Much of dad's libraries we transfreered with Dr Yunus to Glasgow University and enditirs og journals of social business, new economics and innovators of Grameen's virtual free nursing school.
Bangladesh offers best intelligence we have seen for sdgs 5 through 1 up to 2008, Search eg 4 1 oldest edu 4.6 newest edu ; .620th century intelligence - ending poverty of half world without electricity -although Keynes 1936 (last chapter General Theiory: Money, Interest, Employment) asked Economists to take hippocratic oath as the profession that ended extreme poverty, most economists have done the opposite. What's not understandable is how educators failed to catalogue the lessons of the handful who bottom-up empowered villages to collaboratively end poverty. There are mainly 2 inteligences to understand- Borlaug on food science -arguable the forst Biointeligence rising ar1950 on; fazle abed on everything that raised life expectancy in tropical village (zero-electricity) asia from low 40s to 60s (about 7 below norm of living with electricity and telecomes). Between 1972 and late 1990s, Abed's lessons catalogued in this mooc had largely built the nation of Bangladesh and been replicated with help of Unicef's James Grant acroo most tropical asian areas. What's exciting is the valley's mr ad mrs steve jobs invted Fazle Abed to share inteligences 2001 at his 65th birthday party. The Jobs and frineds promised to integrate abed's inteligence into neighborhod university stanfrd which in any event wanted Jobs next great leap the iphone. The Valley told abed to start a university so that women graduates from poor and rich nations could blend inteligence as Abed's bottom of the pyramid vilage began their journey of leapfrog modles now that grid infrastructures were ni longer needed for sdiar and mobile. Abed could also help redesign the millennium goals which were being greenwashed into a shared worldwide system coding frame by 2016. There at Abed's 80th birtday party , the easy bit was checking this mooc was uptodate. The hard bit - what did Abed mean by his wish to headhunt a Taiwanese American to head the university's 3rd decade starting 2020?

Wednesday, July 28, 2021

world bank, dhaka branch,  jan 2015 

The ‘science of delivery’, or bringing the right kinds of services effectively to the poor, is the key to eradicate extreme poverty, said Sir Fazle Hasan Abed, the founder and chairman of BRAC, the world’s largest NGO. 


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The under-five child mortality in Bangladesh has decreased from 180 deaths per 1,000 live births in the 1980s to 53 deaths per 1,000 live births in 2011. The child survival rate in Bangladesh has surpassed that in neighboring countries.

smail Ferdous/World Bank

While visiting the World Bank Bangladesh office, he shared how perfecting the science of delivery helps reduce poverty; saves lives; brings prosperity; and how one impact is linked with another.

In 1972 BRAC started working on integrated rural development in Bangladesh. The country had an alarmingly low child survival rate at the time. Diarrhea was among the leading causes of the death of children. BRAC took the lead in popularizing the Oral Rehydration Therapy (ORT) to prevent diarrhea. Bangladesh now has the world’s highest ORT usage rate. Thanks to ORT and the later success in child immunization, the under-five child mortality in Bangladesh has decreased from 180 deaths per 1,000 live births in the 1980s to 53 deaths per 1,000 live births in 2011. The child survival rate in Bangladesh has surpassed that in neighboring countries.

A mother needs boiled water, sugar and salt from her kitchen to prepare ORT. A simple solution, but the challenge was to reach the millions of mothers, teach them how to prepare the saline solution and ensure the proper feeding of sick children.

BRAC employed female health workers from the community to go door to door and teach mothers to prepare and administer ORT. The rural and often illiterate mother would need to remember 7 simple points of ORT.  The health workers used to mark their utensils to measure half a liter of water, adding a pinch of salt with the fingertips and a fistful of molasses, a substitute to sugar in villages.

“BRACs methodology always focuses on strong monitoring mechanism to measure the progress of any intervention and maintain quality and accountability,” says Sir Abed. BRAC representatives would randomly monitor 10 percent of households. Each health worker received 10 Takas ($.12) per household if the mother could remember the 7 points of ORT accurately.

Unfortunately, the first round of monitoring showed a disappointing 6 percent household usage rate.  BRAC realized that the health workers themselves did not believe in the intervention. BRAC trained the health workers to show how ORT works. The new found belief in the intervention increased the usage rate to 19%, but still far below making a meaningful impact nationally.

Further analysis showed that men felt undermined by not being adequately engaged. BRAC workers started to engage the fathers. To cut time and cost by half, workers started teaching mothers in groups instead of an one on one basis and monitoring the monitors.  Meetings were organized in markets, schools and mosques to explain the benefits of ORT. National TV and radio launched a campaign to popularize ORT.  Once the whole village was mobilized, the results were remarkable.

Sir Abed said, “It involved several incremental steps to deliver the desirable service to the poor. First, making the program effective; second, refining the intervention based on the trial and error to make it efficient; and third, a focus on robust monitoring and accountability mechanism allowing the scaling up of the intervention nationwide.

Citing examples of interlinked development impacts, Sir Abed highlighted that the fertility rate among Bangladeshi women declined during the same period. Bangladesh today has almost achieved a replacement level fertility rate of 2.2 children per women.

The experience shows that through efficient delivery, simple local solutions can bring positive changes in the lives of millions. And to do so, we need to identify effective and available avenues of delivery, easy ways of scaling up the initiative, learn from the failures and rectify. We learn, at each stage, vigilant monitoring, impact assessment, and quick redesigns to improve the intervention.

The delivery mechanism in ORT initiative reconciles with many projects within the Bank to reach out to the poorest of the society.  This experience  can be applied to bring services to millions of people worldwide for poverty reduction and human development.

Bangladesh has shown remarkable progress through simple solutions as ORT. These efforts could be replicated as a model in any development project world-wide,” remarked Sir Abed ending his knowledge sharing with staff in the Dhaka office.

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