DCAI--AI & Childhood Cancer ...AP July 2025 - INTELLIGENCE ENGINEERING'S ALPHABET : World Class Biobrains: Drew Endy, Matt Scullin, Daniel Swiger++- BI BioIntelligence, the most collaborative human challenge Mother Earth has ever staged?
NB any errors below are mine alone chris.macrae@yahoo.co.uk but mathematically we are in a time when order of magnitude ignorance can sink any nation however big. Pretrain to question everything as earth's data is reality's judge
Its time to stop blaming 2/3 of humans who are Asian for their consciously open minds and love of education. Do Atlantic people's old populations still trust and celebrate capability of generating healthy innovative brains? What's clear to anyove visting Washington DC or Brussels is a dismal mismatch exists between the gamechanging future opportunities listed below and how freedom of next generation learning has got muddled by how old male-dominated generations waste money on adevrtising and bossing. Consider the clarity of Stanford's Drew Endy's Strange Competition 1 2:
Up to “60% of the physical inputs to the global economy”7 could be made via biotechnology by mid-century, generating ~$30 trillion annually in mostly-new economic activity. 8 Emerging product categories include consumer biologics (e.g., bioluminescent petunias,9 purple tomatoes,10 and hangover probiotics11 ), military hard power (e.g., brewing energetics12 ), mycological manufacturing (e.g., mushroom ‘leather’ 13 ), and biotechnology for technology (e.g., DNA for archival data storage14 ). Accessing future product categories will depend on unlocking biology as a general purpose technology15 (e.g., growing computers16 ), deploying pervasive and embedded biotechnologies within, on, and around us (e.g. smart blood,17 skin vaccines,18 and surveillance mucus19 ), and life-beyond lineage (e.g., biosecurity at birth,20 species de-extinction21 ).
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notes on drew endy testimony on bio tech 2025 strange competition

Natural living systems operate and manufacture materials with atomic precision on a planetary scale, powered by ~130 terawatts of energy self-harvested via photosynthesis

Biotechnology enables people to change biology. Domestication and breeding of plants and animals for food, service, and companionship began millennia ago. Gene editing, from recombinant DNA to CRISPR, is used to make medicines and foods, and is itself half-a-century old. Synthetic biology is working to routinize composition of bioengineered systems of ever-greater complexity

 https://colossal.com/  20 https://dspace.mit.edu/handle/1721.1/34914  19 https://2020.igem.org/Team:Stanford  18 https://med.stanford.edu/news/all-news/2024/12/skin-bacteria-vaccine.html  17 https://www.darpa.mil/news/2024/rbc-factory  16 https://www.src.org/program/grc/semisynbio/semisynbio-consortium-roadmap/  15 https://www.scsp.ai/2023/04/scsps-platform-panel-releases-national-action-plan-for-u-s-leadership-in-biotechnology/  14 https://dnastoragealliance.org/  13 https://www.mycoworks.com/  12 https://serdp-estcp.mil/focusareas/3b64545d-6761-4084-a198-ad2103880194  11  https://zbiotics.com/  10 https://www.norfolkhealthyproduce.com/  9 https://light.bio/     8 https://web.archive.org/web/20250116082806/https:/www.whitehouse.gov/wp-content/uploads/2024/11/BUILDIN G-A-VIBRANT-DOMESTIC-BIOMANUFACTURING-ECOSYSTEM.pdf  7 https://www.mckinsey.com/industries/life-sciences/our-insights/the-bio-revolution-innovations-transforming-econo mies-societies-and-our-lives     6 https://www.nationalacademies.org/our-work/safeguarding-the-bioeconomy-finding-strategies-for-understanding-ev aluating-and-protecting-the-bioeconomy-while-sustaining-innovation-and-growth   5 https://doi.org/10.1038/s41586-020-2650-9  

  4 https://www.nature.com/articles/s41467-023-40199-9

AIH- May 2025.Billion Asian womens end poverty networking 2006-1976 is most exciting case of Entrepreneurial Revolution (survey Xmas 1976 Economist by dad Norman Macrae & Romano Prodi). In 2007, dad sampled 2000 copies of Dr Yunus Social Business Book: and I started 15 trips to Bangladesh to 2018- many with apprentice journalists. This is a log of what we found - deepened after dad's death in 2010 by 2 kind remembrance parties hoist by Japan Embassy in Dhaka with those in middle of digital support of what happened next. We witnessed a lot of conflicts - i can try and answer question chris.macrae@yahoo.co.uk or see AI20s updates at http://povertymuseums.blogspot.com. I live in DC region but see myself as a Diaspoira Scot. Much of dad's libraries we transfreered with Dr Yunus to Glasgow University and enditirs og journals of social business, new economics and innovators of Grameen's virtual free nursing school.
Bangladesh offers best intelligence we have seen for sdgs 5 through 1 up to 2008, Search eg 4 1 oldest edu 4.6 newest edu ; .620th century intelligence - ending poverty of half world without electricity -although Keynes 1936 (last chapter General Theiory: Money, Interest, Employment) asked Economists to take hippocratic oath as the profession that ended extreme poverty, most economists have done the opposite. What's not understandable is how educators failed to catalogue the lessons of the handful who bottom-up empowered villages to collaboratively end poverty. There are mainly 2 inteligences to understand- Borlaug on food science -arguable the forst Biointeligence rising ar1950 on; fazle abed on everything that raised life expectancy in tropical village (zero-electricity) asia from low 40s to 60s (about 7 below norm of living with electricity and telecomes). Between 1972 and late 1990s, Abed's lessons catalogued in this mooc had largely built the nation of Bangladesh and been replicated with help of Unicef's James Grant acroo most tropical asian areas. What's exciting is the valley's mr ad mrs steve jobs invted Fazle Abed to share inteligences 2001 at his 65th birthday party. The Jobs and frineds promised to integrate abed's inteligence into neighborhod university stanfrd which in any event wanted Jobs next great leap the iphone. The Valley told abed to start a university so that women graduates from poor and rich nations could blend inteligence as Abed's bottom of the pyramid vilage began their journey of leapfrog modles now that grid infrastructures were ni longer needed for sdiar and mobile. Abed could also help redesign the millennium goals which were being greenwashed into a shared worldwide system coding frame by 2016. There at Abed's 80th birtday party , the easy bit was checking this mooc was uptodate. The hard bit - what did Abed mean by his wish to headhunt a Taiwanese American to head the university's 3rd decade starting 2020?

Tuesday, November 25, 2025

 you imply science increasingly lost some openness from 1970 who was it changed this law and did nobody feel this robbed future generations from freedom of learning

The Shift Toward Less Openness in Scientific Publishing from the 1970sYou're right that I highlighted a trend: scientific publishing became less "open" starting around the 1970s, but this wasn't primarily a change in "law" itself. Instead, it was a combination of evolving copyright practices (like stricter enforcement and copyright transfer agreements) and broader legal reforms that extended terms and tightened controls. These changes arose from economic pressures in academia and publishing, amplified by technologies like photocopying. The core issue? Publishers increasingly treated scientific articles as commercial assets, using copyright to control access and distribution—often at the expense of the free-flowing ethos of science.This shift created barriers: rising journal prices (the "serials crisis" of the 1980s–90s), paywalls behind subscriptions, and restrictions on sharing that clashed with science's need for reuse and building on prior work. It didn't "rob" openness overnight, but over decades, it locked away knowledge that taxpayers and researchers funded, limiting who could access or remix it.Who "Changed" This? Key Players and DriversNo single villain flipped a switch, but commercial publishers, supported by lobbying groups, drove the practical enforcement of stricter copyright. Laws provided the framework, but publishers exploited it. Here's the breakdown:
Era & Change
Key Drivers/Advocates
What Happened
1970s: Rise of Commercial Control
Commercial publishers (e.g., Elsevier, Springer, Wiley) entering from trade books; learned societies losing ground.
Post-WWII boom in science led to more papers, but learned societies couldn't handle volume. Commercial firms acquired journals, raised prices 10–20x inflation rates, and started requiring full copyright transfer from authors (previously rare in science). Photocopying exploded, so publishers sued libraries (e.g., Williams & Wilkins v. US, 1975—publishers lost, but it sparked CCC).
1976: US Copyright Act
US Congress, influenced by publishers and authors' groups (e.g., Authors Guild).
First major overhaul since 1909; automatic protection for unpublished works, no formalities needed. Extended terms to life + 50 years (from 28 + 28 renewable). Made it easier for publishers to claim and enforce rights over journals.
1980s–90s: Enforcement & Serials Crisis
Publishers via Copyright Clearance Center (CCC, founded 1978); groups like Association of American Publishers.
CCC created a pay-per-copy system for articles, turning sharing into revenue. Subscriptions soared (e.g., 300% price hikes 1980–2000), forcing libraries to cut access. Publishers lobbied against "piracy" like interlibrary loans.
1993–98: Term Extensions
EU: Commercial publishers & creative industries (e.g., via GESAC). US: Disney/MPAA/RIAA (pushed Sonny Bono Act); publishers joined for journals.
EU harmonized to life + 70 years (Directive 93/98/EEC). US Sonny Bono Act (1998) added 20 years (to life + 70 or 95 from publication), retroactively locking works like 1920s journals until ~2020s. Often called "Mickey Mouse Protection Act" for Disney's influence, but scientific publishers benefited by extending control over archives.
2000s+: Digital Lockdown
Publishers (Elsevier sued ResearchGate 2017; ACS/Elsevier v. Sci-Hub ongoing).
DMCA (1998) added anti-circumvention rules, blocking digital sharing. Rise of "hybrid" journals charged for open access on top of subscriptions.
Publishers argued this protected "investment" in editing/printing, but critics say it prioritized profits: Elsevier's 37% margins dwarf Big Pharma's. Authors signed transfers for prestige, not cash—yet lost reuse rights.Did Nobody Notice? Outrage Over "Robbing Future Generations"Far from unnoticed, this sparked massive backlash from scientists, librarians, and economists. Many explicitly called it a theft from future learners: locking publicly funded research behind paywalls hinders innovation, excludes Global South scholars, and slows cumulative progress (e.g., data mining old papers for AI breakthroughs). WWII-era data shows breaking copyrights boosted US science by 25% via cheaper access. Here's the outcry:
  • Open Access Movement (1990s–now): Budapest Open Access Initiative (2002) declared: "Copyright should not restrict access to knowledge." Led by SPARC, PLOS; argues publishers "parasitize" free labor (authors/reviewers unpaid). Result: 50%+ of new papers open access by 2023.
  • Sci-Hub & Civil Disobedience: Alexandra Elbakyan's Sci-Hub (2011) bypasses paywalls for 85M+ papers, called "ethical piracy" by users. Publishers sue, but it's "civil disobedience" to reclaim science. As one EFF piece puts it: "Copyright requires acts of rebellion to keep science going."
  • Academic & Policy Pushback:
    • 2002 Akerlof et al. letter to Congress: Extensions "rob future generations."
    • 2012 Finch Report (UK): Urged open access to avoid "knowledge divide."
    • EU's 2022 study: Copyright hinders reuse; calls for TDM exceptions.
    • 2015 JASSS paper: Simulations show longer terms decrease scientific output by 10–20%.
  • Global South Voices: Excludes 80% of researchers; "neocolonial" enclosure of knowledge. Plan S (2018, 24+ countries) mandates open access by 2021.
Publishers counter: "We invest in quality." But evidence shows openness accelerates science (e.g., COVID preprints sped vaccines). The fight continues—2025's EU reforms aim to force more reuse rights. Bottom line: Many did feel robbed, and they're fighting back, proving science's ethos endures despite the law

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